ChiCTR1900021273.

Trial name or title	Clinic results of intraductal meibomian gland probing combined intense pulsed light in treating patients with refractory obstructive meibomian gland dysfunction: a randomized controlled trial
Methods	Study design: randomised controlled trial Study grouping: parallel group Exclusions after randomisation? Not applicable Percentage of participant follow‐up: not applicable Study duration (of intervention): not reported Was a sample size calculation reported: not reported
Participants	Baseline characteristics IPL + intraductal probing group Number of participants (number of eyes): 30 (not reported) Sex: not reported Age: not reported Intraductal probing group Number of participants (number of eyes): 30 (not reported) Sex: not reported Age: not reported IPL Number of participants (number of eyes): 30 (not reported) Sex: not reported Age: not reported Overall Number of participants (number of eyes): 90 (not reported) Sex: not reported Age: not reported Inclusion criteria: aged > 18 years; Fitzpatrick skin type 1–4; SPEED questionnaire ≥ 6; meibum grade ≤ 24 and more than half of the 15 evaluated meibomian gland orifices in each eyelid were obstructed and had no lipid secretion with extrusion; TBUT ≤ 5 seconds; Schirmer test > 5 seconds; Meibo‐Scan (OCULUS) showed the atrophy area of meibomian gland in both upper and lower eyelids < 1/3 of the total area; did not have symptom relief with conservative treatment (eyelid warming, massage and artificial tears) for ≥ 1 year before study treatment; sign informed consent Exclusion criteria: history of corneal contact lens, mite blepharitis, acute eye inflammation or infection and apparent eyelid margin scar as well as patients using lacrimal plug or receiving LASIK Significant pretreatment baseline differences? Not applicable Severity of dry eye: not specifically reported, although intends to recruit people with "refractory obstructive meibomian gland dysfunction."
Interventions	IPL + intraductal probing Description: intraductal MGP combined IPL Duration: not reported Co‐interventions: not reported Standard therapy only Description: intraductal MGP Duration: not reported Co‐interventions: not reported IPL only Description: IPL Duration: not reported Co‐interventions: not reported
Outcomes	Primary outcomes: SPEED score TBUT corneal fluorescein staining Secondary outcomes: lid margin finding results mebium grade
Starting date	Recruiting status: recruiting (as at 18 September 2019)
Contact information	Study leader: Jin Xiuming Eye Center, Affiliated Second Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Shangcheng District, Hangzhou, China Email: lzyjxm@zju.edu.cn Telephone: +86 571 87783897
Notes	None