NCT03194698.

Trial name or title	Efficacy of IPL treatment of dry eye and ocular rosacea
Methods	Study design: randomised controlled trial Study grouping: parallel group Exclusions after randomisation? (If Yes, provide relevant details from the paper): not reported Percentage of participant follow‐up (include details from all intervention groups): not reported Study duration (of intervention): 4 months Was a sample size calculation reported? (Yes/No): no
Participants	Baseline characteristics IPL group Number of participants (number of eyes): not reported Sex: not reported Age: not reported Control group Number of participants (number of eyes): not reported Sex: not reported Age: not reported Overall Number of participants (number of eyes): estimated 20 (40) Sex: not reported Age: not reported Inclusion criteria: dry eye of moderate severity with ocular rosacea diagnosed by ophthalmologist; dry eye symptoms must be alleviated with topical anaesthetic; must have ≥ 50% meibomian glands viable on meibography; contact lenses and refractive surgery are permitted; aged 18–100 years; either gender Exclusion criteria: healthy volunteers; contraindications of severe ocular surface disease or inability to be safely treated with IPL; GVHD, Stevens‐Johnson syndrome, active allergic conjunctivitis or other conjunctivitis, alkali burn history; new treatments for dry eye in past 6 months Significant pretreatment baseline differences? Not reported Severity of dry eye: moderate
Interventions	IPL Description of the intervention: not reported Duration of the intervention: treatment with 4 visits and 4 treatments over 4 months Co‐interventions: MGX Control Description of the intervention: MGX only (no IPL) Duration of the intervention: treatment with 4 visits and 4 treatments over 4 months Co‐interventions: none
Outcomes	Primary outcome: OSDI survey at 4 months Secondary outcomes: pathological microbial load (analysis of RNA of ocular microbiome in tear samples) TGF‐beta‐1 growth cytokine level (analysed from tear samples) at 4 months
Starting date	17 August 2017
Contact information	Joanne F Shen Department of Ophthalmology – Arizona, Mayo Clinic, Scottsdale, Arizona, US, 85259 Email: not reported Telephone: not reported
Notes	None