Table 1.
Mucins related to respiratory disease
| Mucin | Chromosome | No. of amino acid repeats | Location of expression in respiratory tract | Respiratory disease association |
|---|---|---|---|---|
| Secreted – gel‐forming | ||||
| MUC2 | 11p15.5 | 16 | Predominantly intestinal but a small amount is found in human lung | Asthma |
| MUC5AC | 11p15.5 | 8 | Upper respiratory tract predominant: trachea and bronchus | COPD, muco‐obstructive lung disease |
| MUC5B | 11p15.5 | 29 | Lower respiratory tract predominant: trachea and bronchus | IPF, RA‐ILD, |
| MUC19 | 12q12 | 7 | Trachea | Unknown |
| Secreted – non‐gel‐forming | ||||
| MUC7 | 4q13.3 | 23 | Saliva | Sjogren's, asthma |
| MUC8 | 12q24.3 | 41 | Maxillary sinus mucosa | Chronic rhinosinusitis, asthma and COPD |
| Membrane bound | ||||
| MUC1 | 1q21 | 20 | Upper and lower respiratory tract | Lung cancer, IPF, COPD |
| MUC4 | 3q29 | 16 | Upper and lower respiratory tract | Lung cancer, COPD, muco‐obstructive lung disease |
| MUC16 | 19p13.2 | 156 | Upper and lower respiratory tract | Lung cancer |