Table 2.
Baseline Cardiac Structure and Function in RELAX Participants by Chronic Kidney Disease Status.
| Chronic Kidney Disease | |||
|---|---|---|---|
| Variable | No (n=98) | Yes (n= 114) | p-value* |
| Left ventricular end diastolic volume index by cMRI (mL/m2), median (IQR) | 53.3 (45.8 – 63.5) | 60.6 (51.0 – 68.5) | 0.07 |
| Left ventricular end systolic volume index by cMRI (mL/m2), median (IQR) | 18.0 (14.1 – 25.3) | 19.5 (15.4 26.0) | 0.26 |
| Stroke volume index (mL/m2), median (IQR) | 36.7 (30.1 – 42.2) | 38.6 (30.2 – 44.3) | 0.49 |
| Ejection Fraction (%), mean (SD) | 60.8 (6.1) | 61.7 (7.3) | 0.22 |
| Left atrial volume index (mL/m2), median (IQR) | 40.7 (31.7 – 54.2) | 48.8 (39.3 – 59.6) | 0.63 |
| Medial e' (m/s), mean (SD) | 0.07 (0.02) | 0.06 (0.02) | 0.07 |
| Lateral e' (m/s), mean (SD) | 0.09 (0.03) | 0.08 (0.03) | 0.04 |
| E/e’ average, median (IQR) | 10.8 (9.4 – 15.4) | 16.3 (11.4 – 22.0) | <0.001 |
| Pulmonary artery systolic pressure (mmHg), mean (SD) | 50.5 (16.1) | 53.7 (15.5) | 0.20 |
| Aortic distensibility by cMRI (10−3 mmHg), median (IQR) | 1.15 (0.67 – 1.79) | 1.19 (0.69 – 1.74) | 0.14 |
| Aortic thickness by cMRI (mm), median (IQR) | 1.3 (1.1 – 1.4) | 1.3 (1.1 – 1.5) | 0.54 |
All indices of cardiac structure and function are derived from echocardiograms unless noted above. CKD was defined as eGFR ≤60 mL/min/1.73m2.
*
Adjusted for age.
cMRI = cardiac magnetic resonance imaging.