Table 3.
Baseline Cardiopulmonary Exercise Test Parameters in RELAX Participants by Chronic Kidney Disease Status.
| Chronic Kidney Disease | |||
|---|---|---|---|
| Variable | No (n=98) | Yes (n= 114) | p-value |
| Resting Variables | |||
| Heart rate (bpm), mean (SD) | 72 (13) | 68 (13) | 0.08 |
| Systolic blood pressure (mmHg), mean (SD) | 127.3 (22.5) | 125.2 (19.1) | 0.47 |
| Diastolic blood pressure (mmHg), mean (SD) | 73.6 (11.9) | 68.6 (9.7) | 0.001 |
| Pulse pressure (mmHg), mean (SD) | 53.7 (17.7) | 56.6 (17.0) | 0.23 |
| Oxygen saturation (%), mean (SD) | 97 (3) | 97 (3) | 0.49 |
| VO2 (mL/kg/min), mean (SD) | 3.1 (0.8) | 3.0 (0.7) | 0.29 |
| Borg score, mean (SD) | 0.6 (1.2) | 0.4 (1.0) | 0.17 |
| Oxygen pulse (mL/beat) | 4.4 (1.1) | 4.5 (1.2) | 0.65 |
| Exercise Variables | |||
| Exercise Mode | 0.52 | ||
| Treadmill, n (%) | 34 (35) | 46 (40) | |
| Bicycle, n (%) | 64 (65) | 68 (60) | |
| Exercise duration (min), mean (SD) | 10.8 (3.1) | 8.6 (2.8) | <0.001 |
| Peak heart rate (bpm), mean (SD) | 118 (24) | 103 (24) | <0.001 |
| Peak systolic blood pressure (mmHg), mean (SD) | 160.8 (32.6) | 146.3 (28.9) | 0.001 |
| Peak diastolic blood pressure (mmHg), mean (SD) | 76.5 (16.2) | 68.9 (12.7) | <0.001 |
| Peak oxygen saturation (%), mean (SD) | 96 (3) | 95 (4) | 0.23 |
| Respiratory exchange ratio | 1.10 (0.09) | 1.10 (0.12) | 0.79 |
| Peak VO2 (mL/kg/min), mean (SD) | 13.5 (2.9) | 11.2 (2.9) | <0.001 |
| Peak Borg score, mean (SD) | 7.2 (2.3) | 6.7 (2.3) | 0.16 |
| 6-minute walk distance (m), mean (SD) | 327.9 (105.0) | 276.5 (111.9) | 0.001 |
| Chronotropic index | 0.58 (0.28) | 0.44 (0.28) | <0.001 |
| Oxygen pulse (mL/beat), mean (SD) | 11.8 (3.1) | 11.1 (2.7) | 0.11 |
6MWD = 6-minute walk distance; VO2 = oxygen consumption. CKD was defined as eGFR ≤60 mL/min/1.73m2.