Mutational landscape of Mucosal Melanoma. Molecular classification of melanoma with BRAF (V600), NRAS (G12, G13, Q61), NF1, KIT and SF3B1 mutations in (A) Mucosal melanoma meta-analysis from 64 studies (B) cutaneous melanoma from TCGA. (C-D) The difference in molecular classifications between mucosal melanomas arising in upper and lower anatomical sites (C) Upper sites include: Head and neck and upper GI. (D) Lower sites include: Lower GI, anorectal, and genital.