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Major events through which inorganic arsenite and its trivalent metabolites disrupt epigenetic integrity via inhibition of epigenetic regulators and chromatin modifiers. As3+, MMAIII, and DMAIII can impair the enzymatic activities of DNA epigenetic regulators (e.g., DNMTs, Tet, and CTCF) and chromatin-modifying enzymes (e.g., hMOF, TIP60, and PARP1), which subsequently perturb DNA methylation and histone PTMs, respectively, thereby disrupting epigenetic integrity.
