Table 1.
Identified Subjects with at Least One ICD-9-CM Code for NMO
| All (n=219) | CHOP (n=34) | CMKC (n=16) | SCH (n=4) | UPHS (n=143) | YNHH (n=22) | |
|---|---|---|---|---|---|---|
| Demographics and Clinical Characteristics | ||||||
| Age, median (IQR) | 39 (17,52) | 12 (6,14) | 8 (5,13) | 12 (11,14) | 44 (32, 56) | 44 (27,54) |
| Female, n (%) | 167 (76%) | 22 (65%) | 11 (69%) | 4 (100%) | 110 (77%) | 20 (9%) |
| White race, n (%) | 104 (51%) | 18 (53%) | 12 (75%) | 1 (25%) | 63 (44%) | 10 (45%) |
| Positive Predictive Values | ||||||
| PPV for NMO/NMOSD | 47% | 41% | 13% | 0% | 48% | 77% |
| PPV for 2006 NMO criteria | 22% | 24% | 6% | 0% | 21% | 41% |
| PPV for 2015 NMOSD criteria | 44% | 41% | 13% | 0% | 45% | 73% |
| PPV for Physician Diagnosis | 67% | 41% | 25% | 50% | 75% | 91% |
Legend. Gold standard is medical chart review demonstrating fulfillment of criteria for NMO and/or NMOSD respectively. IQR= interquartile range. PPV = positive predictive value. CHOP = The Children’s Hospital of Philadelphia. SCH = Seattle Children’s Hospital. CMKC = Children’s Mercy Kansas City. YNHH = Yale-New Haven Hospital. UPHS = the University of Pennsylvania Health System. NMO = neuromyelitis optica. NMOSD = neuromyelitis optica spectrum disorder.