Table 2.
Positive Predictive Value (PPV) for Case-Finding Algorithms for NMO/NMOSD Clinical Criteria
| Combined PPV (n=219) | Pediatric PPV (n=54) | Adult PPV (n=165) | |
|---|---|---|---|
| ICD-9 code 341.0 | |||
| ≥ 2 codes | 59% (76/128) | 52% (14/27) | 61% (62/101) |
| ≥ 3 codes | 66% (65/98) | 69% (11/16) | 66% (54/82) |
| ≥ 4 codes | 72% (57/79) | 83% (10/12) | 70% (47/67) |
| ≥ 5 codes | 73% (54/74) | 83% (10/12) | 71% (44/62) |
| ICD-9 + no MS code | |||
| ≥ 2 codes + no MS | 63% (50/79) | 57% (13/23) | 66% (37/56) |
| ≥ 3 codes + no MS | 75% (41/55) | 71% (10/14) | 76% (31/41) |
| ≥ 4 codes + no MS | 80% (35/44) | 82% (9/11) | 79% (26/33) |
| ≥ 5 codes + no MS | 81% (33/41) | 82% (9/11) | 80% (24/30) |
| ICD-9 + corticosteroids | |||
| ≥ 2 codes + corticosteroids | 64% (55/86) | 58% (14/24) | 66% (41/62) |
| ≥ 3 codes + corticosteroids | 70% (45/64) | 73% (11/15) | 69% (34/49) |
| ≥ 4 codes + corticosteroids | 77% (41/53) | 91% (10/11) | 74% (31/42) |
| ≥ 5 codes + corticosteroids | 78% (39/50) | 91% (10/11) | 74% (29/39) |
| Codes + Hospitalized | |||
| ≥ 2 codes + hospitalized | 61% (48/79) | 59% (13/22) | 61% (35/57) |
| ≥ 3 codes + hospitalized | 65% (39/60) | 77% (10/13) | 62% (29/47) |
| ≥ 4 codes + hospitalized | 69% (34/49) | 90% (9/10) | 64% (25/39) |
| ≥ 5 codes + hospitalized | 71% (32/45) | 90% (9/10) | 92% (23/35) |
| Codes + Subspecialist | |||
| ≥ 2 codes + subspecialist | 62% (70/113) | 54% (14/26) | 64% (56/87) |
| ≥ 3 codes + subspecialist | 68% (60/88) | 73% (11/15) | 67% (49/73) |
| ≥ 4 codes + subspecialist | 75% (53/71) | 91% (10/11) | 72% (43/60) |
| ≥ 5 codes + subspecialist | 76% (50/66) | 91% (10/11) | 73% (40/55) |
| Codes + CNS imaging | |||
| ≥ 2 codes + CNS imaging | 62% (72/117) | 54% (13/24) | 63% (59/93) |
| ≥ 3 codes + CNS imaging | 67% (61/91) | 67% (10/15) | 67% (51/76) |
| ≥ 4 codes + CNS imaging | 73% (55/75) | 83% (10/12) | 71% (45/63) |
| ≥ 5 codes + CNS imaging | 74% (52/70) | 83% (10/12) | 72% (42/58) |
| Codes + corticosteroids + CNS imaging | |||
| ≥ 2 codes + corticosteroids + CNS imaging | 65% (52/80) | 57% (13/23) | 68% (39/57) |
| ≥ 3 codes + corticosteroids + CNS imaging | 71% (42/59) | 71% (10/14) | 71% (32/45) |
| ≥ 4 codes + corticosteroids + CNS imaging | 78% (39/50) | 91% (10/11) | 74% (29/39) |
| ≥ 5 codes + corticosteroids + CNS imaging | 79% (37/47) | 91% (10/11) | 75% (27/36) |
CNS= central nervous system and imaging includes any one of the following: computed tomography of the head, magnetic resonance imaging of the brain, magnetic resonance imaging of the orbits or magnetic resonance imaging of the spine. Corticosteroids includes either oral and/or intravenous corticosteroids. Hospitalization includes any hospitalization for any indication within 30 days prior to or 30 days after the first documented ICD-9-CM code for NMO. MS= multiple sclerosis and no codes for MS indicates there were no documented ICD-9-CM codes for MS (340) at any time in the patient’s medical record. Subspecialist indicates that the patient was seen by either a rheumatologist, ophthalmologist and/or neurologist within 6 months prior to or 6 months after the initial documented ICD-9 code for NMO. The number of codes indicates the minimum number of codes for NMO (341.0) documented at any point throughout the patient’s medical record.