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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Semin Cancer Biol. 2019 Nov 2;61:158–166. doi: 10.1016/j.semcancer.2019.10.016

Figure 1. Fumarate hydratase (FH) function and the locus of the FH gene.

Figure 1.

The FH gene is located at chr1q43. It encodes for the fumarate hydratase enzyme (FH). FH catalyzes the reversible conversion of fumarate to malate in the TCA cycle. FH also takes part in DNA Damage Response (DDR) signaling, whereby FH is recruited to the DNA damage (i.e. DNA double strand break) site, where it catalyzes the conversion of malate to fumarate, which serves as a signal to promote non-homologous end joining (NHEJ).