Table 2.

MMPs (1, 9) and TIMPs (2, 4) clearly distinguish PTB from EPTB, LTB, and/or HC individuals.

	PTB vs. EPTB				PTB vs. LTB				PTB vs. HC
	Sensitivity	Specificity	P	AUC	Sensitivity	Specificity	P	AUC	Sensitivity	Specificity	P	AUC
MMP-1	95.59	84.09	<0.0001	0.9418	98.53	100	<0.0001	0.9993	100	100	<0.0001	1.000
MMP-2	61.76	61.36	0.0965	0.5932	52.94	50.00	0.6723	0.5237	57.35	52.27	0.2577	0.5635
MMP-3	57.35	56.82	0.2730	0.5615	57.35	54.55	0.5238	0.5358	57.35	54.55	0.3055	0.5575
MMP-7	61.76	72.73	0.0347	0.6185	50.00	50.00	0.0410	0.6146	57.35	61.36	0.2836	0.5602
MMP-8	72.06	72.73	<0.0001	0.8496	66.18	77.27	<0.0001	0.7988	67.65	70.45	<0.0001	0.7741
MMP-9	80.88	84.09	<0.0001	0.9094	73.53	75.00	<0.0001	0.8763	72.06	79.55	<0.0001	0.8469
MMP-12	74.00	65.91	<0.0001	0.7694	63.24	75.00	<0.0001	0.7602	75.00	81.82	<0.0001	0.8319
MMP-13	63.24	100	0.0156	0.6357	51.47	81.82	0.6464	0.5257	48.53	75.00	0.7658	0.5167
TIMP-1	69.12	77.27	0.0056	0.6554	70.59	84.09	0.0004	0.6999	69.12	68.18	0.0042	0.6608
TIMP-2	95.59	95.45	<0.0001	0.9576	100	95.45	<0.0001	0.9853	100	97.73	<0.0001	0.9923
TIMP-3	81.82	84.09	<0.0001	0.8285	64.71	95.45	0.0325	0.6200	64.71	97.73	0.0183	0.6324
TIMP-4	100	100	<0.0001	1.0000	98.53	95.45	<0.0001	0.9789	100	97.73	<0.0001	0.9866

ROC analysis was performed to determine the sensitivity, specificity, and area under the curve using the plasma levels of MMPs (1, 2, 3, 7, 8, 9, 12, 13) and TIMPs (1, 2, 3, 4) between PTB vs. EPTB, PTB vs. LTB and PTB vs. HC to calculate the ability of these factors to distinguish PTB from EPTB, LTB and HC individuals. Highest discrimination were represented in bold.