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. 2020 Mar 11;8:42. doi: 10.3389/fped.2020.00042

Figure 2.

Figure 2

Histopathological findings in multiple biopsy specimen. Native kidney biopsy taken before the start of any immunosuppression shows interstitial infiltration of the lymphohistiocytic cells, with CD80 positivity only in single cells. Infiltrates are not associated with tubular atrophy. DAB staining at low power (×10) (a) and at high power (×40) (b). Kidney transplant biopsy shows minimal interstitial infiltration in the vicinity of atrophic tubules, which is not indicative of rejection. No interstitial infiltrates are seen here compared to native kidney tissue [periodic acid–Schiff (PAS) staining, ×20] (c–f). Small bowel biopsies under immunosuppression with locotypical interstitial lymphocytes with dominance of T cells, partly of cytotoxic subtype (CD8-positive), while CD80 positivity can only be seen in single cells [(g–j) at low power, ×10]: (g) HE staining, (h) CD3 DAB staining, (i) CD80 DAB staining, and (j) CD8 DAB staining. Pancreas biopsy prior to transplantation/start of immunosuppression shows interstitial infiltrates and demonstrates CD80 positivity in single cells. DAB staining at low power (×10) (k) and at high power (×40) (l).