Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jan 24;11(2):268–280. doi: 10.1111/jdi.13202

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

PMC Copyright notice

Pancreatic stellate cell activation and islet fibrosis in type 2 diabetes mellitus (T2DM). High‐glucose levels, insulin and angiotensin II (Ang II), and a release of pro‐inflammatory cytokines induce pancreatic stellate cell (PSC) activation. Activated PSCs cause extracellular matrix production and cell proliferation. These phenomena appear to drive fibrosis within the pancreatic islets in type 2 diabetes mellitus. Islet fibrosis can be detected by immunostaining for alpha‐smooth muscle actin (α‐SMA) and trichrome. LETO, Long‐Evans Tokushima Otsuka; OLETF, Otsuka Long Evans Tokushima fatty; RAS, renin–angiotensin system.