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dsRNA-mediated SjPhb1 knockdown in vivo resulted in a decreased egg production and attenuated granuloma formation and fibrosis in the liver of their mammalian host. (a–c) H&E staining of the mouse liver sections at 42 days post-infection (dpi). (d–f) Masson staining of the mouse liver sections at 42 dpi. (a,d) SjPhb1 dsRNA injection. (b,e) EGFP dsRNA injection. (c,f) 0.7% NaCl injection. (g) Comparison of egg count per paired worms per gram of the liver weight of mouse. ∗∗P = 0.001.
