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. 2020 Feb 11;20:242–251. doi: 10.1016/j.omtn.2020.02.001

Figure 1.

Figure 1

STZ-Induced Diabetic Model with DR

(A and B) Effects of streptozotocin (STZ) on blood glucose (A) and body weight (B) levels of C57BL/6 mice. (C) The expressions of Col IV in retinas of C57 and STZ-induced diabetic mice were examined by quantitative real-time PCR. N = 4 per group; *p < 0.05, STZ group versus C57 group. (D) Fluorescein fundus angiography (FFA) of C57 and STZ-induced diabetic mice. (E) Retinal capillaries of C57 and STZ-induced diabetic mice were shown by hematoxylin and PAS staining. Arrows point to acellular capillaries. (F) TEM of retinal capillaries of C57 and STZ-induced diabetic mice. Arrows point to cavity-like structures.