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. 2020 Mar 11;11:354. doi: 10.3389/fimmu.2020.00354

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Copyright © 2020 Queck, Bode, Uschner, Brol, Graf, Schulz, Jansen, Praktiknjo, Schierwagen, Klein, Trautwein, Wasmuth, Berres, Trebicka and Lehmann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Levels of MCP-1 in peripheral blood (A), expression of CCL2 in liver (B), and PBMC (C) and correlation of blood MCP-1 with expression of CCL2 in liver (D) and PBMC (E) of healthy control, bile-duct ligated and ACLF rats. Mann–Whitney test and Spearman's rank correlation. Rats minimum N ≥ 5 per group. MCP-1, monocyte chemoattractant protein-1; CCL2; ACLF, acute on chronic liver failure; PBMC, peripheral blood mononuclear cells; BDL, bile duct ligation; LPS, lipopolysaccharide; P < 0.05 were considered statistically significant.