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. 2020 Mar 11;10:217. doi: 10.3389/fonc.2020.00217

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Copyright © 2020 Meng, Wang, Zhao, Hu, Zhi, Wei, Ruan, Hou, Li, Zhang, Yang, Qian, Wu, Zhang, Meng, Guan, Zhang, Zheng and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of autophagy enhanced the suppression of PTC growth by apatinib in vivo. (A) Images of tumors dissected from mice in the four groups (DMSO control group, HCQ single-treatment group, apatinib single-treatment group, and apatinib and HCQ combined treatment group) inoculated with K-1 cells. (B) Tumor weights in the four groups. (C) Tumor volumes in the four groups. (D) Mouse weights in the four groups. (E) HE and IHC staining to detect cleaved caspase 3 and Ki-67 in the four groups. Data are expressed as the mean ± SD (*P < 0.05, **P < 0.01, ***P < 0.001).