Fig. 3. An irregular echo pattern was associated with the development of destructive thyroiditis and/or hypothyroidism in patients treated with anti-PD-1 antibodies.

Representative images showing regular (a) and irregular (b) echo patterns in the thyroid in a patient who was positive for anti-thyroid antibodies at baseline. The cumulative incidence of destructive thyroiditis and/or hypothyroidism was significantly higher in patients with irregular than in those with regular echo patterns among the patients treated with pembrolizumab (c), nivolumab (d) and pembrolizumab or nivolumab (e), respectively.