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. 2020 Jan 28;122(6):885–894. doi: 10.1038/s41416-020-0729-6

Fig. 3. LA promotes pro-IGF-1R accumulation and reduces mature IGF-1R expression.

Fig. 3

MCF7 and MDA-MB-231 breast cancer cell lines were treated with EtOH 2% (NT) or with LA (1 or 2 mM) for 24, 48 and 72 h. Pro-IGF-1R and mature IGF-1R expressions were detected by western blot analysis after 48 and 72 h of LA treatment (1 or 2 mM) in a MCF7 (ERα+) and b MDA-MB-231 (ERα−) cell lines. c IGF-1R protein expression and localisation were evaluated by immunofluorescence in MCF7 cells treated with 1 or 2 mM of LA for 24 and 48 h, as indicated.