Table 2.
Five SNPs showed significant association with one of the tested three cohorts either separately or/and as a pooled samples.
| Locus | Nearest Gene(s) | A1 | A2 | Stage | OR | L95 | U95 | P(Q) | I2 | Mod | P | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | rs2771342 | |||||||||||
| 14q11.2 | METTL17 (downstream to RNASE2) | C | T | AgP-Ger | 1.12 | 0.99 | 1.26 | 0.08 | ||||
| AgP-NL | 0.92 | 0.73 | 1.16 | 0.49 | ||||||||
| CP-EA-mod | 1.15 | 1.04 | 1.28 | 0.00 | ||||||||
| CP-EA-sev | 1.13 | 0.98 | 1.30 | 0.08 | ||||||||
| Pooled | 1.12 | 1.05 | 1.19 | 0.37 | 0.04 | FE | 7.41E-04 | |||||
| CP-Ger | 1.19 | 1.05 | 1.36 | 0.01 | ||||||||
| Pooled (all) | 1.13 | 1.07 | 1.20 | 0.42 | 0.00 | FE | 2.84E-05 | |||||
| 2 | rs9695213 | |||||||||||
| 9p24.1 | MRRF (upstream to TTLL11, downstream PTGS1) | G | A | AgP-Ger | 1.19 | 1.00 | 1.42 | 0.05 | ||||
| AgP-NL | 1.38 | 0.99 | 1.93 | 0.06 | ||||||||
| CP-EA-mod | 1.27 | 1.09 | 1.48 | 0.00 | ||||||||
| CP-EA-sev | 1.22 | 0.99 | 1.50 | 0.07 | ||||||||
| Pooled | 1.24 | 1.13 | 1.37 | 0.86 | 0.00 | FE | 7.91E-06 | |||||
| CP-Ger | 1.01 | 0.84 | 1.22 | 0.88 | ||||||||
| Pooled (all) | 1.19 | 1.09 | 1.30 | 0.34 | 0.12 | FE | 5.77E-05 | |||||
| 3 | rs1780616 | |||||||||||
| 20q11.23 | AL391095.1 - LBP | T | C | AgP-Ger | 1.14 | 1.01 | 1.29 | 0.04 | ||||
| AgP-NL | 1.25 | 0.98 | 1.58 | 0.07 | ||||||||
| CP-EA-mod | 1.07 | 0.97 | 1.19 | 0.18 | ||||||||
| CP-EA-sev | 1.17 | 1.01 | 1.35 | 0.04 | ||||||||
| Pooled | 1.13 | 1.05 | 1.20 | 0.62 | 0.00 | FE | 5.44E-04 | |||||
| CP-Ger | 1.01 | 0.88 | 1.15 | 0.92 | ||||||||
| Pooled (all) | 1.10 | 1.04 | 1.17 | 0.42 | 0.00 | FE | 1.67E-03 | |||||
| 4 | rs9271850 | |||||||||||
| HLA-DQH1 | ||||||||||||
| A | G | AgP-Ger | 1.53 | 1.34 | 1.74 | 2.54E-10 | ||||||
| AgP-NL | 1.66 | 1.32 | 2.09 | 1.75E-05 | ||||||||
| Meta-AgP | 1.56 | 1.39 | 1.75 | 0.54 | 0.00 | FE | 2.52E-14 | |||||
| 5 | rs17214512 | |||||||||||
| HLA-DPA1 | ||||||||||||
| A | G | AgP-Ger | 1.31 | 1.12 | 1.54 | 9.53E-04 | ||||||
| AgP-NL | 1.44 | 1.07 | 1.93 | 1.64E-02 | ||||||||
| Meta-AgP | 1.34 | 1.16 | 1.54 | FE | 5.14E-05 | |||||||
(AgP-Ger; The German AgP samples, AgP-NL; Dutch AgP samples, Mod-CP; European American moderate CP cases, Sev-CP; European American severe CP cases, CP-Ger; German CP samples, A1 = Effect allele; A2 = Non-effect allele; EAF = Effect allele frequency; Cas = Cases; Con = Controls; OR = Odds ratio; CI = Confidence interval; P(Q) = Cochranes Q P-value; I2 = Heterogeneity index; Mod = Model; RE = Random effects; FE = Fixed effects; P = P-value).