Table 4.

Prognostic factors of RFS; univariate and multivariate analyses.

	Univariate analysis		Multivariate analysis
Covariate	p value	Hazard ratio [95% CI]	p value	Hazard ratio [95% CI]
Age (ref ≤70 years old)	0.6025	0.85 [0.45; 1.59]
Tumour staging (ref T2)	0.0001	3.46 [1.84; 6.49]	NS
Node staging (ref N0)	0.3808	1.33 [0.70; 2.55]
Histological type (ref ductal)	0.3620
Lobular carcinoma		1.54 [0.81; 2.93]
Other		0.71 [0.10; 5.30]
Histological grade (ref I)	0.9640	0.98 [0.45; 2.14]
Baseline ER Allred score (refs. 5–7)	0.9899	a
Baseline Ki-67 (ref ≤10%)	0.0681	2.12 [0.95; 4.73]	NS
Treatment (ref anastrozole)	0.4090	1.30 [0.69; 2.45]
Study (ref CARMINA02)	0.1326	1.63 [0.86; 3.10]	NS
Clinical response (ref OR)	0.3136	1.38 [0.73; 2.61]
Pathological response (ref TA or TB and NA or NB)	0.9846	b
Pathological tumour size (ref pT1–2)c	0.0012	3.36 [1.61; 7.00]
Node status (ref pN negative)c	0.0007	4.22 [1.84; 7.00]
ER Allred score at surgery (refs. 5–7)c	0.1340	2.07 [0.80; 5.39]
Ki-67 at surgery (ref ≤10%)c	0.0093	2.61 [1.27; 5.38]
Adjuvant chemotherapy (ref no)	0.0167	2.27 [1.16–4.43]	NS
PEPI group (refs I and II)	0.0004	4.40 [1.94; 10.00]	0.0069	3.33 [1.39; 7.98]

Bold values indicate variables statistically significant with p value  <  0.15 (backward selection) included in the multivariate analysis. Since the proportionality assumption was not satisfied for the variable ‘Pathological response’, multivariate analysis was stratified on this variable.

ref reference, OR objective response as per RECIST 1.1, NS not statistically significant, PEPI preoperative endocrine prognostic index.

^aHazard ratio not calculable because of unbalanced figures (only two ER Allred scores <6–8).

^bHazard ratio not calculable (no events were observed in pathological responders).

^cFactors accounted for in the ‘PEPI group’ variable.