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. 2020 Jan 16;122(6):868–884. doi: 10.1038/s41416-019-0711-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a–d Box and whisker plots of fatty acid metabolism gene mRNA expression levels (z-scores) in human breast cancer patient tumours from the METBRIC database. Tumours were classified based on the PAM50 + claudin-low molecular subtyping of breast cancer as called by the METABRIC database. Claudin-low, n = 182; Basal, n = 198; HER2, n = 218; Luminal A, n = 673; Luminal B, n = 454; Normal-like, n = 135. Boxes represent 25th to 75th percentile, whiskers represent min to max, and lines represent medians; p values were determined using an ordinary one-way ANOVA and Dunnett’s multiple comparison test. e–h Scatter plots of mRNA expression of CD36 against LPL, PDGFRB, PDK4, and FABP4 in CL-TNBC. Black lines represent linear regression of scatter plots. Spearman correlation r values and p values are reported on graphs. i, j Kaplan–Meier survival plots of patients with basal-TNBC (j) and CL-TNBC (i). Patients were stratified based on the expression of CD36, LPL, PDK4, and FABP4 as described in the results; p values were calculated using log-rank test. Hazard ratios (HR) are shown on the plots. k–m Box and whisker plots of Ca²⁺ transporter mRNA expression levels (z-scores) in CL-TNBC patient tumours. Tumours were divided in those with diploid, copy number gains, and amplification of MYC as called by the METBRIC database. Boxes represent 25th to 75th percentile, whiskers represent min to max, and lines represent medians; p values are reported on the graphs and were determined using an ordinary one-way ANOVA and Dunnett’s multiple comparison test. n Box and whisker plots of Ca²⁺ transporter mRNA expression levels (z-scores) in CD36^Hi versus CD36^Lo CL-TNBC patient tumours. Boxes represent 25th to 75th percentile, whiskers represent min to max, and lines represent medians; p values were determined using an unpaired Student’s t-test; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, N.S. = not significant.