Table 1.

Potential therapeutic targets against M. pachydermatis.

EC Number	Abbreviature	Enzyme	Human Match	% Protein similarity
4.2.1.19	IGPD	Imidazoleglycerol-phosphate dehydratase	NA	NA
2.5.1.78	RIBH	6,7-Dimethyl-8-ribityllumazine synthase	NA	NA
2.5.1.9	RIB	Riboflavin synthase	NA	NA
2.3.3.14	HCS	Homocitrate synthase	HMGCL	14.4
1.1.1.3	HSD	homoserine dehydrogenase	PSB5	18.31
1.5.1.7; 1.5.1.10	SDH	Saccharopine dehydrogenase	F8WE53	19.71
4.2.1.36	HACN	Homoaconitate hydratase	ACON	21.36
1.1.1.41; 1.1.1.42	IDH	Isocitrate dehydrogenase	IDH3A	32.72
1.14.13.70	CYP51A1	Lanosterol 14 alpha-demethylase	CP51A	36.48
2.7.4.22	UK	Uridylate kinase	KCY	40.7
1.3.1.-	ERG4/ERG24	Ergosterol biosynthesis sterol reductase ERG4/ERG24	LBR	41.18
5.4.2.8	PMM	Phosphomannomutase	H3BV55	51.06
6.4.1.1	PC	Pyruvate carboxylase	PC	51.43
3.6.1.9	ITPA	Inosine triphosphate pyrophosphatase	ITPA	52.91
6.3.4.5	AS	Argininosuccinate synthase	ASSY	55.3

The in-silico deletion of these enzymes resulted in a decrease in the production of biomass of at least 30%. The percentage of similarity and human match to the human proteome is also shown. Prioritized enzymes are shown in bold and underline.