Fig. 4. Model predictions presented as logistic regression outcomes for multivariate and raw outcome for univariate analyses by time.

Time is years to diagnosis for cases and years since final sample for controls. Model cut-offs giving 90.3% specificity are indicated by horizontal dashed lines. Grey lines represent individuals and circles the time the sample was taken. The thick line is a Loess fit over all points with 95% CIs in grey shading. Vertical dashed lines indicate the timepoint at which the Loess curve intersects the threshold for model CA125{5}.