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. 2020 Mar 17;10:4864. doi: 10.1038/s41598-020-61858-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of HP diet on bone metabolism, aortic calcification, and renal calcification in OVX rats (Experiment 1): Scatter plots represent individual rats (n = 8), and horizontal bars through the plots indicate the mean values (a–f). Columns with error bars represent the mean ± SEM of eight rats. (g) Bars or columns with different letters are significantly different (p < 0.05). (a) Lumbar vertebral bone mineral density. (b) Serum CTX/TRACP5b ratio (bone resorption index). (c) Abdominal aortic calcium concentration. (d) Abdominal aortic phosphorus concentration. (e) Renal calcium concentration. (f) Renal phosphorus concentration. (g) Urinary total protein excretion at 2nd, 4th, 8th, and 12th weeks. NP, normal phosphorus diet; HP, high phosphorus diet; OVX, ovariectomy.