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. 2020 Mar 11;11:177. doi: 10.3389/fphys.2020.00177

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Copyright © 2020 Ding, Tang, Tang, Zhu, Liu, Pan, Hu, Lin, Gou, Yuan, Cai, Dong, Wang and Ren.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of PA on FOXO1, ER stress, and necroptosis in AML12 cells. (A) Immunoblot analysis of FoxO1, p-FoxO1, PERK, GRP78, CHOP, RIP1, RIP3, p-MLKL in CD and HFD feeding mice. (B) Immunoblot analysis of FoxO1, p-FoxO1, PERK, GRP78, CHOP, RIP1, RIP3, p-MLKL in cells treated with PA. (C) Quantitative analysis of (A). (D) Quantitative analysis of (B) ^∗P < 0.05 vs. CD controls. t-Test, data are shown as mean ± standard deviation.