TABLE 2.
Top 40 genes with greatest fold changes in LD subjects relative to healthy donors
| Gene symbol(s) | Gene title(s) | Entrez gene(s) | Fold change |
||
|---|---|---|---|---|---|
| Acute | 1 mo | 6 mo | |||
| DEFA1/DEF1B/DEF3A | Defensin, alpha 1/defensin, alpha 1B/defensin, alpha 3, neutrophil specific |
1667/1668/728358 | 5.21 | 3.73 | 3.24 |
| LCN2 | Lipocalin 2 | 3934 | 3.95 | 2.59 | 1.00 |
| FCGR3B | Fc fragment of IgG, low-affinity IIIb, receptor (CD16b) |
2215 | 3.86 | 2.67 | –1.07 |
| MYL9 | Myosin, light chain 9, regulatory | 10398 | 3.42 | 2.35 | –1.74 |
| FCGR1A | Fc fragment of IgG, high-affinity Ia, receptor (CD64) |
2209 | 3.34 | 1.38 | 1.25 |
| CLU | Clusterin | 1191 | 3.12 | 2.06 | –1.76 |
| RRM2 | Ribonucleotide reductase M2 | 6241 | 3.06 | 1.29 | –1.27 |
| GMPR | Guanosine monophosphate reductase | 2766 | 2.88 | 2.03 | –1.15 |
| IGHM | Immunoglobulin heavy constant mu | 3507 | 2.84 | 2.05 | –1.71 |
| PF4 | Platelet factor 4 | 5196 | 2.83 | 2.56 | –1.27 |
| SPARC | Secreted protein, acidic, cysteine-rich (osteonectin) |
6678 | 2.77 | 2.09 | –1.45 |
| PPBP | Pro-platelet basic protein (chemokine [C-X-C motif] ligand 7) |
5473 | 2.82 | 2.48 | –1.22 |
| C21orf7 | Chromosome 21 open reading frame 7 | 56911 | 2.70 | 2.41 | –1.27 |
| TNFSF10 | Tumor necrosis factor (ligand) superfamily, member 10 |
8743 | 2.77 | 1.87 | 1.43 |
| HSPA6/HSPA7 | Heat shock 70-kDa protein 6/heat shock 70-kDa protein 7 |
3310/3311 | 2.76 | 2.12 | 1.25 |
| C6orf25 | Chromosome 6 open reading frame 25 | 80739 | 2.75 | 2.06 | –1.17 |
| HIST1H2BK | Histone cluster 1, H2bk | 85236 | 2.74 | 2.11 | –1.67 |
| MYL9 | Myosin, light-chain 9, regulatory | 10398 | 2.72 | 1.86 | –1.45 |
| CXCR2/CXCR2P1 | Chemokine (C-X-C motif) receptor 2/chemokine (C-X-C motif) receptor 2 pseudogene 1 |
3579/3580 | 2.72 | 1.87 | –1.12 |
| FCGR1B | Fc fragment of IgG, high-affinity 1b, receptor (CD64) |
2210 | 2.70 | 1.23 | –1.06 |
| SLC25A37 | Solute carrier family 25, member 37 | 51312 | 2.68 | 1.88 | –1.29 |
| GBP1 | Guanylate binding protein 1, interferon inducible, 67 kDa |
2633 | 2.68 | 1.80 | 1.56 |
| HP | Haptoglobin | 3240 | 2.68 | 1.32 | 1.07 |
| AIM2 | Absent in melanoma 2 | 9447 | 2.67 | 2.19 | 1.42 |
| CA2 | Carbonic anhydrase II | 760 | 2.63 | 2.41 | –1.18 |
| HIST1H2AG | Histone cluster 1, H2ag | 8969 | 2.62 | 2.16 | 1.37 |
| PTGS1 | Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) |
5742 | 2.61 | 2.15 | –1.01 |
| THBS1 | Thrombospondin 1 | 7057 | –4.30 | –5.64 | 1.49 |
| IL8 | Interleukin 8 | 3576 | –3.44 | –3.88 | 1.79 |
| EGR1 | Early growth response 1 | 1958 | –3.40 | −2.87 | 1.14 |
| G0S2 | G0/G1 switch 2 | 50486 | –3.10 | –3.77 | 1.02 |
| PPP1CB | Protein phosphatase 1, catalytic subunit, beta isozyme |
5500 | –3.02 | −2.71 | −1.04 |
| NR4A2 | Nuclear receptor subfamily 4, group A, member 2 |
4926 | −2.80 | –2.85 | 1.16 |
| HBEGF | Heparin-binding EGF-like growth factor | 1839 | –2.96 | –3.46 | 1.15 |
| RGS1 | Regulator of G-protein signaling 1 | 5996 | –2.94 | –2.70 | 1.12 |
| EPPK1 | Epiplakin 1 | 83481 | –2.94 | –2.44 | −1.22 |
| TNFAIP3 | Tumor necrosis factor, alpha-induced protein 3 |
7128 | –2.79 | –2.51 | 1.08 |
| NAMPT | Nicotinamide phosphoribosyltransferase | 10135 | –2.75 | –3.98 | 1.84 |
| CD69 | CD69 molecule | 969 | –2.67 | –2.50 | −1.04 |
| CD83 | CD83 molecule | 9308 | −2.67 | −2.50 | 1.29 |