FIG 4.

Convergent recombination drives selection of persistent but not nonpersistent TCR repertoire: decreased number of nucleotide additions in CDR3 of persistent EBV-specific TCR repertoire. (A, B, D, and E) Number of nucleotide additions in the CDR3 of YVL-BR-specific (A and B) and GLC-BM-specific (D and E) TCRα and TCRβ of persistent, nonpersistent, and de novo repertoires (A and D) and private versus public clonotypes (B and E). (C and F) Increased usage of glycines in the longer CDR3 of the de novo TCR repertoire. Data were analyzed by multivariant two-way ANOVA with correction for multiple comparisons. *, P < 0.05; **, P < 0.01; ***, P < 0.001. Error bars are SEM.