FIG 5.

CDR3α and CDRβ length distributions of YVL-BR- and GLC-BM-specific CD8 T cells in AIM and CONV (A) and in persistent, de novo, and nonpersistent clonotypes (B) differ. (A) The mean CDR3 length distribution of the 3 EBV-infected patients’ TCR repertoire was analyzed by deep sequencing of tetramer-sorted cells during AIM and CONV. (B) The TCR repertoires were analyzed also after dividing each patient’s samples into 3 groups, those that persist from AIM into CONV and those which do not, as well as de novo clonotypes arising in CONV. Data were analyzed by multivariant two-way ANOVA with correction for multiple comparisons. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001. Error bars are SEM.