Fig. 2.

In vivo model validation. Model simulation outputs for NPs of size a) 46 nm, b) 69 nm, c) 113 nm, and d) 162 nm are shown as blue lines in various model compartments. Red dots and error bars represent mean ± S.D. of the experimental data from the literature for mesoporous silica NPs of matching hydrodynamic sizes (n = 4 animals per group). Note: y-axes are in logarithmic scale. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)