Table 2.

List of estimated model parameters.

Parameter	Description (Units)	Calculation	Value
			Tumor		Healthy
			Estimated	Literature (Reference)	Estimated	Literature (Reference)
$\mathit{u}$	Capillary blood flow velocity (μm⋅s−1)	Eq. (S40)	30	0–200 [73]	553	100–1000 [8], [70], [74]
${\mathit{Q}}_{\mathbf{c}\mathbf{a}\mathbf{p},\mathit{i}}$	Capillary blood volumetric flow rate (nl⋅min−1)	Eq. (S39)	0.15	0.21 (ischemia) [75]	2.58	2.4–3.47 [8], [70]
$\dot{\mathit{\gamma }}$	Capillary shear rate (s−1)	Eq. (S41)	16	0–30 [73]	116	100–1000 [61], [70], [74]
${\mathit{\sigma }}_{\mathit{i}}$	Reflection coefficient	Eqs. (6), (S36), (S37)	n/a		Liver: 0.43, Spleen: 0.0025, Others: 1 (reference NP size 10 nm); also see Fig. S4a	Liver, spleen: 0.85 Others: 0.9–0.99 (reference NP size ~ 10 nm) [65]
$\mathit{P}$	Permeability (mm⋅s−1)	Eq. (7)	1.1 × 10−7 (reference NP size 90 nm); 1.27 × 10−6 (reference NP size 9.4 nm); also see Fig. S4b	2 × 10−7 (reference NP size 90 nm) [76]; 2.82 × 10−6 (reference NP size 9.4 nm) [77]	n/a
$\mathit{S}$	Surface area (mm2/mm3)	Section 3 of SI	40	34–45 [78]	n/a