Vacarezza 2010.

Methods	Randomised, double‐blinded study (outpatients), single‐blinded (inpatients)
Participants	Adult males and females > 18 years
Interventions	Oral clarithromycin versus oral amoxicillin for outpatients study arm
Outcomes	Primary: clinical response. Secondary: adverse effects
Notes	Article in Spanish; translation done by Dr. RA Rodriguez, Dr. Gonzalo Alvarez and Dr. Jacqueline Sandoz (Department of Medicine, University of Ottawa) Hospitalised patients are included in the study but separate results for inpatients and outpatients are provided. Study conducted in Uruguay
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Block randomisation by PORT score was used
Allocation concealment (selection bias)	Unclear risk	Not explicitly stated
Blinding (performance bias and detection bias) All outcomes	Unclear risk	No explicit mention of patient and assessor blinding
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	No CONSORT diagram presented, therefore reasons for exclusion of patients at the entry level are unclear
Selective reporting (reporting bias)	Low risk	The study reported on every patient that was included in the trial
Other bias	Low risk	No financial conflicts