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. 2020 Mar 11;10:278. doi: 10.3389/fonc.2020.00278

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Copyright © 2020 Cheng and Shen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of miR-335 enhanced proliferation and migration, while disturbing G1 phase arrest and apoptosis by recovering ROCK1. (A) The cell proliferation of A375 and B16 cells expressing miR-335 inhibitor or miR-335 inhibitor plus si-ROCK1 at the indicated time points. (B) The cell cycle distribution of A375 and B16 cells expressing miR-335 inhibitor or the combination. (C) Apoptosis of A375 and B16 cells expressing miR-335 inhibitor or the combination. (D,E) Migration of A375 and B16 cells expressing miR-335 or miR-335 plus ROCK1. (F,G) The expression of the indicated genes in the cells expressing miR-335 inhibitor or the combination was determined by Western blot and RT-PCR, separately. *P < 0.05 vs. control, ^#P < 0.05 vs. miR-335 inhibitor. Data gained in three independent experiments. The results are presented as the mean ± standard deviation.