Weinfurt 2008a.
Methods | Randomised controlled trial | |
Data | Setting: community, USA. 3623 participants aged 18 or over and diagnosed with coronary artery disease | |
Comparisons | Intervention A: drug company pays investigator running costs plus general statement saying ethics committee did not think this would affect patient safety Intervention B: drug company pays investigator money for things outside the study plus general statement saying ethics committee did not think this would affect patient safety Intervention C: Investigator owns part of drug company plus general statement saying ethics committee did not think this would affect patient safety. Intervention D: Institution owns part of drug company plus general statement saying ethics committee did not think this would affect patient safety Comparator: generic financial disclosure: general statement about investigator possibly gaining financially plus general statement saying ethics committee did not think this would affect patient safety |
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Outcomes | Willingness to take part in hypothetical trial | |
Notes | ||
Risk of bias | ||
Item | Authors' judgement | Description |
Random Sequence generation ok? | Unclear | Randomisation mentioned but no more details |
Allocation concealment? | Unclear | See above |
Blinding of participants and personnel ok? | Unclear | Not clear what participants were told about the purpose of the study although there were 5 disclosure statements so everyone got a statement (i.e. hard to tell which group they were in). Participants completed a questionnaire (probably) so research team unable to influence |
Blinding of outcome assessment ok? | Unclear | See above |
Incomplete outcome data handled ok? | Unclear | Only P values presented, not absolute numbers |
Free of selective reporting? | Yes | Willingness to participate outcome presented, which is all the review needs |
Was the study free of other bias? | No | Hypothetical trial |
Overall bias? | Yes | High risk of bias |