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Major enzymatic reactions involving glutathione. Conjugation reactions with an electrophilic donor are catalyzed by glutathione‐S‐transferases (GST). Reduction of the substrate such as H2O2, lipid peroxide (LOOH), and peroxynitrite (ONOO−) are catalyzed by glutathione peroxidases (GPx). Disulfide bond reduction can be catalyzed by glutaredoxins (Grx). The reduction of glutathione disulfide (GSSG) to glutathione is catalyzed by the glutathione reductase (GR) and required NADPH
