Table 2.
Feeding Parameters
| Variable | Total Population, n = 423 | Sepsis, n = 297 | No Sepsis, n = 126 | P a |
|---|---|---|---|---|
| Time to start feeding, hours, median [IQR] | 6.0 [3.2–15.5] | 6.1 [3.3–14.5] | 5.7 [2.9–17.2] | 0.844 |
| Patients parenterally fed, days 1–3, n (%) | 40 (9.5) | 33 (11.1) | 7 (5.6) | 0.074 |
| Patients parenterally fed, days 4–7, n (%) | 39 (9.2) | 29 (9.8) | 10 (7.9) | 0.552 |
| Protein intake | ||||
| Daily protein target, g, mean (SD) | 115.5 (20.9) | 113.8 (20.6) | 119.3 (21.2) | 0.013e |
| Total protein intake 7 days, g, mean (SD) | 522.19 (154.6) | 517.5 (148.0) | 532.8 (169.1) | 0.352 |
| Protein intake days 1–3, g/kg/d, median [IQR] | 0.72 [0.42–0.97] | 0.75 [0.44–0.99] | 0.59 [0.34–0.91] | 0.010e |
| <0.8, n (%) | 249 (58.9) | 166 (55.9) | 83 (65.9) | |
| 0.8–1.2, n (%) | 140 (33.1) | 103 (34.78) | 37 (29.4) | |
| >1.2, n (%) | 34 (8.0) | 28 (9.4) | 6 (4.8) | |
| Protein intake days 4–7, g/kg/d, mean (SD) | 1.21 (0.30) | 1.21 (0.31) | 1.21 (0.29) | 0.976 |
| <0.8, n (%) | 35 (8.3) | 24 (8.1) | 11 (8.7) | |
| 0.8–1.2, n (%) | 161 (38.1) | 116 (39.1) | 45 (35.7) | |
| >1.2, n (%) | 227 (53.7) | 157 (52.9) | 70 (55.6) | |
| Energy intake | ||||
| Daily energy target in kcalb, mean (SD) | 1704 (324) | 1694 (321) | 1727 (331) | 0.340 |
| Daily energy target in kcal, based on VCO2 c, mean (SD) | 1818 (366) | 1798 (376) | 1863 (340) | 0.234 |
| Total energy intake in kcald, mean (SD) | 9871 (2436) | 9877 (2419) | 9857 (2486) | 0.937 |
| Adequacy energy intake to targetb , d, days 1–3, mean % (SD) | 67.2 (28.6) | 69.4 (28.5) | 62.1 (28.3) | 0.016e |
| <80%, n (%) | 268 (63.4) | 178 (59.9) | 90 (71.4) | |
| 80%–110%, n (%) | 130 (30.7) | 102 (34.3) | 28 (22.2) | |
| >110%, n (%) | 25 (5.9) | 17 (5.7) | 8 (6.3) | |
| Adequacy energy intake to targetb , d, days 4–7, mean % (SD) | 107 (25) | 107 (24) | 107 (27) | 0.760 |
| <80%, n (%) | 49 (11.6) | 34 (11.4) | 15 (11.9) | |
| 80%–110%, n (%) | 233 (55.1) | 158 (53.2) | 75 (59.5) | |
| >110%, n (%) | 141 (33.3) | 105 (35.4) | 36 (28.6) | |
| Non‐nutrition energy as % of total energy intake, median [IQR] | 7.7 [3.6–15.7] | 7.6 [4.0–15.9] | 8.5 [3.0–15.0] | 0.886 |
IQR, interquartile range; SD, standard deviation.
a
Comparison of sepsis with non‐sepsis group, calculated with t‐test or Mann‐Whitney U test where appropriate.
b
Target based on World Health Organization formula for resting energy expenditure + 20%.
c
Target based on mean daily VCO2 × 8.19.
d
Nutritional + non‐nutritional energy.
e
P < 0.05.