Figure 4.

Mutations in recurrences are independent of molecular subtype stability. Each row in (a) represents a patient and each split box represents a tumor: the upper third is colored by FGFR3 mutation status, the middle third by the PIK3CA mutation status and the lower third by the TERT mutation status. Patients and tumors are organized as in Figure 3. (b) Molecular data for a patient with four tumors stably classified as Urothelial‐like (UroA–UroA–UroA–UroB), for which every tumor's mutation status differs from the rest. (c) Molecular data for a patient with a primary UroA tumor that changed subtype to basal/squamous in the progression tumor. The two tumors showed different FGFR3 and PIK3CA mutations. (d) Molecular data for a patient with a primary GU tumor that changed subtype to Basal/Squamous in the progression tumor. The two tumors showed identical mutation profile. [Color figure can be viewed at http://wileyonlinelibrary.com]