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. 2019 Nov 27;68(5):989–998. doi: 10.1002/glia.23757

Figure 2.

Figure 2

Direct desialylation of microglia by a sialidase or sialyl‐transferase inhibitor increases phagocytosis of 5 μm beads. (a) FITC‐conjugated lectin peanut agglutinin (PNA‐FITC) binding to sialidase treated or sialyl‐transferase inhibitor (ST‐Inh)‐treated BV‐2 microglia. Data presented as mean FL‐1 fluorescence values, with error bars presenting SEM of at three independent experiments. Statistical analysis was performed by one‐way ANOVA with Tukey's post hoc test, ****p < .0001. (b) Phagocytic uptake of 5 μm beads by BV‐2 microglia. (c) Phagocytic uptake of 5 μm beads by primary rat microglia. Data presents the percentage of cells containing beads normalized to the vehicle condition. Error bars represent SEM of three independent experiments. Statistical analysis was performed by one‐way ANOVA with Sidak's post hoc test **p < .01, ***p < .001, ****p < .0001