Table 5b.
Univariate and multivariate analyses of clinicopathologic findings and SCNA pattern subgroups as predictors of metachronous metastasis in clear cell renal cell carcinoma of the second cohort
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| Variables | HR | 95% CI | P | HR | 95% CI | P |
| Size, mm | ||||||
| >40 vs ≤40 | 6.465 | 1.747‐41.722 | .0035* | 0.724 | 0.033‐7.746 | .7909 |
| Fuhrman grade | ||||||
| 3 vs 2 | 1.641 | 0.568‐5.002 | .3579 | |||
| Necrosis | ||||||
| Present vs absent | 2.435 | 0.843‐7.426 | .0990 | |||
| Venous invasion | ||||||
| Positive vs negative | 8.882 | 2.864‐30.892 | .0002* | 6.762 | 0.524‐87.231 | .1354 |
| pT stage | <.0001* | .3242 | ||||
| pT2 vs pT1 | 9.079 | 1.991‐46.288 | .0056 | 3.658 | 0.344‐79.816 | .2755 |
| pT3 vs pT1 | 18.120 | 4.281‐102.586 | <.0001* | 1.257 | 0.053‐57.720 | .8925 |
| pT3 vs pT2 | 1.996 | 0.526‐9.332 | .3181 | 0.344 | 0.044‐3.756 | .3486 |
| CNA pattern subgroup | ||||||
| 2 vs 1 | 9.256 | 2.470‐60.122 | .0004* | 9.274 | 1.259‐93.825 | .0293* |
Abbreviations: CI, confidence interval; CNA, copy number alteration; HR, hazard ratio; SCNA, somatic copy number alteration.
*
P < .05.