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. 2019 Nov 26;95(2):472–490. doi: 10.1111/brv.12573

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© 2019 The Authors. Biological Reviews published by John Wiley & Sons Ltd on behalf of Cambridge Philosophical Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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BRV-12573-FIG-0002-c — Calmodulin‐binding proteins are differentially regulated under hypertonic stress. A transcriptomic approach by Na et al. (2007) revealed genes that are differentially expressed at various time points (0–120 min) during hypertonic stress. Gene enrichment analysis of the 809 genes through the Gene Ontology (GO) database revealed an enrichment of calmodulin binding proteins (CaMBPs) (GO: 0005516). A binomial test was used to determine the enriched genes on the GO database. Seven of the identified genes encoded CaMBPs (listed to the right of the heat map); these are shown in the heat map with the associated log‐fold changes at various time points. A dendrogram (left of the heat map) describes the similarity in the transcriptional changes at various time points.