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. 2019 Nov 6;51(3):793–805. doi: 10.1111/ejn.14597

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© 2019 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Proteomic analysis of PSD95‐TAP/Grik4‐Cre complexes reveals a subset of the hippocampal PSD‐95 interactome. The composition of PSD‐95 complexes isolated from constitutive PSD95‐TAP and PSD95‐cTAP/Grik4‐Cre mice was compared to control purifications using label‐free quantitative mass spectrometry. (a) Volcano plot of proteins enriched in constitutive PSD95‐TAP purifications from hippocampal tissue versus wild‐type controls. A total of 103 proteins were significantly enriched (permutation‐based FDR; red and green), and 53 of these were also enriched in PSD95‐cTAP/Grik4‐Cre purifications (green). (b) Volcano plot of proteins enriched in PSD95‐cTAP/Grik4‐Cre purifications from hippocampal tissue versus wild‐type controls. Sixty‐two proteins were significantly enriched (permutation‐based FDR; green and blue), 9 of which were not enriched in constitutive PSD95‐TAP purifications from hippocampal tissue (blue). (c) Venn diagram of proteins enriched in constitutive hippocampal PSD95 complexes and PSD95‐cTAP/Grik4‐Cre complexes compared to hippocampal tissue controls. CA3‐restricted (Grik4‐Cre) PSD95 complexes are a subset of the total hippocampal PSD95 interactome [Colour figure can be viewed at http://wileyonlinelibrary.com]