Figure 6.

DNA shaping parameter tilt and propeller twist (ProT) are proportional to mid‐section triplet (5′‐TAANNNAATCA‐3′) alterations. The two DNA shaping parameter base tilt (A) and ProT (B) were displayed for the forward motif of the DUX4 aptamer while permuting the pyrimidines of the second base triplet of the motif (CCT, TCT, CTT, TTT, CTC, TCC, CCC, TTC). The sequences were sorted by increasing IC50 values (dark blue to yellow). The DNA shape values were predicted using the R package DNAshapeR