Table 3.
HRs (95% CI) of death from all causes according to standardised scores on attitudes to ageing scales at age 72 years, adjusted for accelerated DNA methylation GrimAge (AgeAccelGrim) and covariates (N=715)
| Adjustments | Physical change | †p/pFDR | Psychosocial loss | †p/pFDR | Psychological growth | †p/pFDR |
| Age and sex | 0.66 (0.56 to 0.78) | <0.001/0.0003 | 1.28 (1.09 to 1.50) | 0.002/0.004 | 0.87 (0.74 to 1.02) | 0.089/0.120 |
| Age, sex and AgeAccelGrim | 0.71 (0.61 to 0.84) | <0.001/0.0003 | 1.23 (1.05 to 1.44) | 0.0011/0.020 | 0.89 (0.75 to 1.03) | 0.110/0.140 |
| Age, sex, education and social class | 0.67 (0.57 to 0.79) | <0.001/0.0003 | 1.25 (1.07 to 1.47) | 0.005/0.009 | 0.84 (0.72 to 0.99) | 0.040/0.064 |
| Age, sex, education and social class plus AgeAccelGrim | 0.72 (0.62 to 0.85) | <0.001/0.0003 | 1.21 (1.03 to 1.42) | 0.020/0.033 | 0.86 (0.73 to 1.01) | 0.065/0.097 |
| Age, sex, smoking and alcohol | 0.69 (0.58 to 0.81) | <0.001/0.0003 | 1.23 (1.05 to 1.44) | 0.011/0.020 | 0.87 (0.74 to 1.02) | 0.088/0.119 |
| Age, sex, smoking and alcohol plus AgeAccelGrim | 0.71 (0.60 to 0.83) | <0.001/0.0003 | 1.22 (1.04 to 1.42) | 0.016/0.029 | 0.86 (0.75 to 1.01) | 0.068/0.100 |
| Age, sex, chronic disease and walking speed | 0.73 (0.61 to 0.86) | <0.001/.0003 | 1.18 (1.01 to 1.39) | 0.043/0.067 | 0.87 (0.75 to 1.02) | 0.092/0.121 |
| Age, sex, chronic disease plus AgeAccelGrim | 0.76 (0.64 to 0.91) | 0.001/0.002 | 1.16 (0.99 to 1.37) | 0.075/0.106 | 0.88 (0.76 to 1.04) | 0.138/0.168 |
| Age, sex, anxiety and depression | 0.67 (0.56 0.80) | <0.001/0.003 | 1.25 (1.03 to 1.51) | 0.021/0.034 | 0.90 (0.77 to 1.07) | 0.233/0.244 |
| Age, sex, anxiety and depression plus AgeAccelGrim | 0.72 (0.60 to 0.86) | <0.001/0.003 | 1.21 (1.00 to 1.45) | 0.048/0.074 | 0.90 (0.77 to 1.06) | 0.225/0.240 |
| All* | 0.76 (0.64 to 0.91) | 0.002/0.004 | 1.15 (0.96 to 1.39) | 0.128/0.159 | 0.87 (0.74 to 1.03) | 0.104/0.135 |
*Age, sex, AgeAccelGrim, educational attainment, social class, total number of chronic diseases, time taken to walk 6 metres, smoking status, frequency of alcohol consumption, HADS anxiety score, HADS depression score.
†pFDR is the p value corrected for multiple comparisons using the False Discovery Rate.
HADS, Hospital Anxiety and Depression Scale.