Figure 4.

Pharmacokinetic characteristics of [¹¹C]2 in healthy rats (n=4, mean values±SD). A: Dynamic PET scan (coronal plane) of all 39 frames of the brain demonstrates brain uptake and distribution suited for imaging with even distribution of [¹¹C]2 in the whole brain. B: Brain uptake of [¹¹C]2 drops after the initial perfusion peak and then slowly increases over time to a maximum uptake after 25 min, after which the activity slowly washes out. C: Ex vivo biodistribution after 75 min uptake time shows median uptake values in the brain between 0.24±0.05 (cerebellum) and 0.30±0.05 %ID/g (brainstem). Organ uptake was highest in the liver with 0.79±0.22 %ID/g.