Table 2.
Information on potential targets and the topological attributes.
| No. | Gene name | Protein name | UniProt ID | Degree |
|---|---|---|---|---|
| 1 | VEGFA | Vascular endothelial growth factor A | P15692 | 41 |
| 2 | TNF | Tumor necrosis factor | P01375 | 40 |
| 3 | IL-6 | Interleukin-6 | P05231 | 39 |
| 4 | MAPK1 | Mitogen-activated protein kinase 1 | P28482 | 37 |
| 5 | CCL2 | C-C motif chemokine 2 | P13500 | 35 |
| 6 | PTGS2 | Alcohol dehydrogenase 1B | P35354 | 34 |
| 7 | IL-1β | Interleukin-1 beta | P01584 | 34 |
| 8 | NOS3 | Nitric oxide synthase, endothelial | P29474 | 34 |
| 9 | JUN | Transcription factor AP-1 | P05412 | 34 |
| 10 | EGFR | Epidermal growth factor receptor | P00533 | 33 |
| 11 | MAPK8 | Mitogen-activated protein kinase 8 | P45983 | 33 |
| 12 | IL-10 | Interleukin-10 | P22301 | 31 |
| 13 | PPARG | Peroxisome proliferator-activated receptor gamma | P37231 | 31 |
| 14 | CXCL8 | Interleukin-8 | P10145 | 31 |
| 15 | MMP2 | 72 kDa type IV collagenase | P08253 | 30 |
| 16 | ESR1 | Estrogen receptor | P03372 | 30 |
| 17 | SERPINE1 | Plasminogen activator inhibitor 1 | P05121 | 30 |
| 18 | TGFB1 | Transforming growth factor beta-1 | P01137 | 28 |
| 19 | SIRT1 | NAD-dependent deacetylase sirtuin-1 | Q96EB6 | 28 |
| 20 | MAPK14 | Mitogen-activated protein kinase 14 | Q16539 | 28 |
| 21 | HIF-1α | Hypoxia-inducible factor 1-alpha | Q16665 | 28 |
| 22 | CAV1 | Caveolin-1 | Q03135 | 26 |
| 23 | SPP1 | Osteopontin | P10451 | 25 |
| 24 | MPO | Myeloperoxidase | P05164 | 25 |
| 25 | MMP3 | Stromelysin-1 | P08254 | 24 |
| 26 | KDR | Vascular endothelial growth factor receptor 2 | P35968 | 24 |
| 27 | NOS2 | Nitric oxide synthase, inducible | P35228 | 23 |
| 28 | SOD1 | Superoxide dismutase (Cu-Zn) | P00441 | 23 |
| 29 | NFE2L2 | Nuclear factor erythroid 2-related factor 2 | Q16236 | 21 |
| 30 | GJA1 | Gap junction alpha-1 protein | P17302 | 20 |
| 31 | CDKN1A | Cyclin-dependent kinase inhibitor 1 | P38936 | 19 |
| 32 | IL-1A | Interleukin-1 alpha | P01583 | 16 |
| 33 | PRKCA | Protein kinase C alpha type | P17252 | 15 |
| 34 | PPARA | Peroxisome proliferator–activated receptor alpha | Q07869 | 14 |
| 35 | IGF2 | Insulin-like growth factor II | P01344 | 14 |
| 36 | PTGS1 | Prostaglandin G/H synthase 1 | P23219 | 13 |
| 37 | HSPA5 | 78 kDa glucose-regulated protein | P11021 | 12 |
| 38 | DPP4 | Dipeptidyl peptidase IV | P27487 | 11 |
| 39 | PRKCB | Protein kinase C beta type | P05771 | 10 |
| 40 | THBD | Thrombomodulin | P07204 | 10 |
| 41 | AKR1B1 | Aldose reductase | P15121 | 8 |
| 42 | PON1 | Serum paraoxonase/arylesterase 1 | P27169 | 8 |
| 43 | INSR | Insulin receptor | P06213 | 8 |
| 44 | BCL2 | Apoptosis regulator Bcl-2 | P10415 | 7 |
| 45 | E2F1 | Transcription factor E2F1 | Q01094 | 6 |
| 46 | LYZ | Lysozyme | P61626 | 5 |
| 47 | HTR2A | 5-hydroxytryptamine 2A receptor | P28223 | 1 |
| 48 | PRSS1 | Trypsin-1 | P07477 | 1 |