Figure 1.

Changes in Crohn's disease management over the past decade.

Before the era of T2T and tight control, patient management was guided by symptoms and only CRP was routinely measured. Other examinations were performed on demand. Residual inflammation could progressively alter the bowel wall and lead to significant damage, with strictures or fistulas requiring disabling surgery.

T2T = treat-to-target; PRO = patient reported outcomes; CRP = C-reactive protein; FC = faecal calprotectin; US = ultrasonography; MRE = magnetic resonance enterography.