Figure 1.

Representative images of the critical sized bone defect. (a) A superior view of the 4 mm defect created in the left parietal bone of 16-week-old male mice at 7 days postdefect introduction with no intervention performed, (b) 14 days postdefect introduction with no intervention performed, and (c) 21 days postdefect introduction with no intervention performed. The images show little to no healing, affirming that a critical sized bone defect that will not heal without external intervention was created.