Table 3.
Anticholinergic (antimuscarinic) adverse drug reactions to amitriptyline
| System | Aggregated variables | Symptom |
|---|---|---|
| Gastrointestinal tract as | Dry mouth-related symptoms | Dry mouth, difficulty chewing, difficulty swallowing, difficulty speaking |
| Digestion-related symptoms | Constipation | |
| Genitourinary tract | Genitourinary-related symptoms | Urinary retention |
| Eye and adnexa | Vision-related symptoms | Blurred vision, disturbances in accommodation, and adaptation |
| Skin | Thermoregulation related symptoms | Hot dry skin, hyperthermia, anidrosis |
| Cardiovascular system | Cardiovascular-related symptoms | Tachycardia, palpitations, tachyarrhythmia |
| Nervous system | 1. Fatigue-related symptoms | Fatigue |
| 2. Attention-related symptoms | Inability to concentrate, confusion, disorientation | |
| 3. Memory-related symptoms | Mild amnesia, memory impairment | |
| 4. Restlessness-related symptoms | Excitement, restlessness, agitation | |
| 5. Coordination-related symptoms | Ataxia, hyperreflexia |