Table 4.

Non-anticholinergic adverse drug reactions to amitriptyline

System	Symptom
Gastrointestinal tract	Sour or metallic taste Stomatitis Gastric irritation Nausea and vomiting
Hypersensitivity reactions	Urticaria Angioedema Photosensitization Cholestatic jaundice Blood disorders such as eosinophilia Bone-marrow depression Thrombocytopenia Leucopenia Agranulocytosis
Endocrine system	Testicular enlargement Gynecomastia Breast enlargement Galactorrhoea Sexual dysfunction Changes in blood sugar concentrations Hyponatremia associated with inappropriate secretion of antidiuretic hormone
Other adverse effects	Increased appetite with weight gain (or occasional anorexia with weight loss) Sweating

Source of data: Martindale: The Complete Drug Reference [33]