Fig. 3.

Representative images of the process of organoids culture from a giant papillary carcinoma patient. a A giant breast mass surgery specimen. b Cut an appropriate size of breast mass for culture and store. c The tumor tissue was cut into 3 mm³ pieces. d You can see the cell mass and fibers when the tumor pieces were digested in collagenase. e Lysis red blood cells if a red precipitate is seen. f Morphology of organoids under microscope at day 1 and 14